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IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor while possessing significantly improved metabolic stability

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Activation of the 2 -adrenergic pathway is the main mechanism by which insulin secretion is inhibited by the SNS 21 hence our strategy was to activate 2 adrenergic receptors on pancreatic -cells to test if this would counteract the hypothesised decrease in SNS activity triggered by OB GLP-1R activation in WD mice

Lyophilized (unreconstituted) peptides remain stable for extended periods when stored frozen or refrigerated away from light and moisture